Hooke
HookeUI's workspace with a live specimen, a question on it and the open-source models it stacks above.

Hooke · open source

Parallel researchers for scientific data.

Stack open-source scientific models across long-horizon tasks, on your Mac and in the cloud at once.Open-source models, stacked on your Mac and in the cloud. For educators, researchers and explorers.

Free, for Macs with Apple silicon and macOS 14 or later.

Many specimens, each worked on by models on a Mac (gold) and in the cloud (blue).

Run a whole lab in parallel.

Researchers fan out across every specimen in your dataset at once, stacking open-source models on your Mac and in the cloud, and keep going on tasks that take hours.

One specimen image with each model's result stacked and aligned on it.

Every model's answer, on the same specimen.

Results line up layer on layer, each named with the model and settings that made it, so anyone can check and repeat them.

Models arranged around one specimen, each switched on or off.

Meet your staff

The open-source models science runs on, one click away.

Segmentation, tracking, classification and Fiji, beside the best cloud models. Switch them on, stack them, and ask about any spot.

Behind every name are people who spent years teaching a model to see one thing well. Hooke brings their work a click from your microscope, and names it on every result it helps make.

Open by design

Bring Hooke to the agent you already use.

Hooke's open-source scientific tools run from Claude and ChatGPT as well as from the Mac app, so your researchers work in the harness you prefer.

Add your own capability. Everyone gets it.

Wrap a model, an algorithm or a Fiji function as one catalog folder, and the community gets it as a catalog update, with no new app. Start from a BioImage Model Zoo or Hugging Face link, a Cellpose model you trained, or have an AI assistant draft its adapter, tried in a sandbox before you use it.

  • Claude
  • ChatGPT
  • HookeUI on your Mac
Hookeone harness for scientific models
  • Hugging Face
  • BioImage Model Zoo
  • Fiji
  • + Your own model

In 1665, Robert Hooke drew a slice of cork and called its little boxes cells.

He published his drawings, so anyone with a lens could look for themselves. We build Hooke in the open for the same reason.

This is a plant stem, today. Cellpose-SAM outlined all 1,523 of its cells in about 20 seconds on a Mac, and the app measured every one. Point at a cell to see what it found.

1,523 cells. Point at one.

The cells of a stained plant stem, as Cellpose-SAM outlined them, drawn from the app’s saved result. Sizes are in pixels: no scale was set.
  • Free, and yours to change

    HookeUI’s own code will be Apache 2.0, with a sign-off on every contribution. The licence is being finalised for the first release.

  • Results anyone can repeat

    Every result keeps the model, version and settings that made it. Share a picture and it names them, so anyone can turn on the same ones and look again.

  • Made by the people who use it

    Add a model, an example or a fix. Share it as a file, or publish it to the reviewed catalog for everyone. The forum opens with the first release.

Free · open source · for Macs with Apple silicon

Come and look.

Hooke is a signed Mac app. Install it with Finder; no terminal or developer tools.

  1. 1

    Download

    Open the disk image.

  2. 2

    Drag to Applications

    Then open HookeUI there.

  3. 3

    First launch

    It prepares its Python and packages, about 350 MB, step by step on screen.

  4. 4

    Open the example

    A real microscope image, its bright regions found and measured on your Mac.

The example and the local models need no key. Chat, voice and naming use a cloud provider, with your own key. Installation details and current limits are on the download page. The source code is published on GitHub with the first public release.